Publications

Wu Q, Xue R, Zhao Y, Ramsay K, Wang EY, Savoji H, Veres T, Cartmell SH, Radisic M. Automated fabrication of a scalable heart-on-a-chip device by 3D printing of thermoplastic elastomer nanocomposite and hot embossing. Bioact Mater. 2023 Nov 7;33:46-60. doi: 10.1016/j.bioactmat.2023.10.019.

Park S, Newton J, Hidjir T, Young EWK. Bidirectional airflow in lung airway-on-a-chip with matrix-derived membrane elicits epithelial glycocalyx formation. Lab Chip. 2023 Aug 8;23(16):3671-3682. doi: 10.1039/d3lc00259d.

Wu Q, Zhang P, O’Leary G, Zhao Y, Xu Y, Rafatian N, Okhovatian S, Landau S, Valiante TA, Travas-Sejdic J, Radisic M. Flexible 3D printed microwires and 3D microelectrodes for heart-on-a-chip engineering. Biofabrication. 2023 Jun 22;15(3):035023. doi: 10.1088/1758-5090/acd8f4.

Sebastian JA, Strohm EM, Baranger J, Villemain O, Kolios MC, Simmons CA. Assessing engineered tissues and biomaterials using ultrasound imaging: In vitro and in vivo applications. Biomaterials. 2023 May;296:122054. doi: 10.1016/j.biomaterials.2023.122054.

Sebastian JA, Strohm EM, Chérin E, Mirani B, Démoré CEM, Kolios MC, Simmons CA. High-frequency quantitative ultrasound for the assessment of the acoustic properties of engineered tissues in vitro. Acta Biomater. 2023 Feb;157:288-296. doi: 10.1016/j.actbio.2022.12.014.

Li NT, Wu NC, Cao R, Cadavid JL, Latour S, Lu X, Zhu Y, Mijalkovic M, Roozitalab R, Landon-Brace N, Notta F, McGuigan AP. An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues. Biomaterials. 2022 Dec;291:121883. doi: 10.1016/j.biomaterials.2022.121883.

Banh L, Cheung KK, Chan MWY, Young EWK, Viswanathan S. Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases. Osteoarthritis Cartilage. 2022 Aug;30(8):1050-1061. doi: 10.1016/j.joca.2022.03.012.

Rajasekar S, Lin DSY, Zhang F, Sotra A, Boshart A, Clotet-Freixas S, Liu A, Hirota JA, Ogawa S, Konvalinka A, Zhang B. Subtractive manufacturing with swelling induced stochastic folding of sacrificial materials for fabricating complex perfusable tissues in multi-well plates. Lab Chip. 2022 May 17;22(10):1929-1942. doi: 10.1039/d1lc01141c.

Lock R, Al Asafen H, Fleischer S, Tamargo M, Zhao Y, Radisic M, Vunjak-Novakovic G. A framework for developing sex-specific engineered heart models. Nat Rev Mater. 2022;7(4):295-313. doi: 10.1038/s41578-021-00381-1.

Lu RXZ, Lai BFL, Rafatian N, Gustafson D, Campbell SB, Banerjee A, Kozak R, Mossman K, Mubareka S, Howe KL, Fish JE, Radisic M. Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation. Lab Chip. 2022 Mar 15;22(6):1171-1186. doi: 10.1039/d1lc00817j.

Wang EY, Kuzmanov U, Smith JB, Dou W, Rafatian N, Lai BFL, Lu RXZ, Wu Q, Yazbeck J, Zhang XO, Sun Y, Gramolini A, Radisic M. An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy. J Mol Cell Cardiol. 2021 Nov;160:97-110. doi: 10.1016/j.yjmcc.2021.06.012.

Park S, Young EWK. E-FLOAT: Extractable Floating Liquid Gel-Based Organ-on-a-Chip for Airway Tissue Modeling under Airflow. Adv Mater Technol. 2021 Oct;6(12):2100828. doi: 10.1002/admt.202100828

Campbell SB, Wu Q, Yazbeck J, Liu C, Okhovatian S, Radisic M. Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems. ACS Biomater Sci Eng. 2021 Jul 12;7(7):2880-2899. doi: 10.1021/acsbiomaterials.0c00640.

Rafatian N, Vizely K, Al Asafen H, Korolj A, Radisic M. Drawing Inspiration from Developmental Biology for Cardiac Tissue Engineers. Adv Biol (Weinh). 2021 Jul;5(7):e2000190. doi: 10.1002/adbi.202000190.

Radisic M, Loskill P. Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices. ACS Biomater Sci Eng. 2021 Jul 12;7(7):2861-2863. doi: 10.1021/acsbiomaterials.1c00831.

Lai BFL, Lu RXZ, Davenport Huyer L, Kakinoki S, Yazbeck J, Wang EY, Wu Q, Zhang B, Radisic M. A well plate-based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nat Protoc. 2021 Apr;16(4):2158-2189. doi: 10.1038/s41596-020-00490-1.

Huyer LD, Mandla S, Wang Y, Campbell S, Yee B, Euler C, Lai BF, Bannerman D, Lin DSY, Montgomery M, Nemr K, Bender T, Epelman S, Mahadevan R, Radisic M. Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity. Adv Funct Mater. 2021 Feb 3;31(6):2003341. doi: 10.1002/adfm.202003341.

Xu L, Song X, Carroll G, You L. Novel in vitro microfluidic platform for osteocyte mechanotransduction studies. Integr Biol (Camb). 2020 Dec 30;12(12):303-310. doi: 10.1093/intbio/zyaa025.

Lai Benjamin FL, Lu Rick X, Hu Y, Davenport HL, Dou W, Wang EY, Radulovich N, Tsao MS, Sun Y, Radisic M. Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature. Adv Funct Mater. 2020 Nov 25;30(48):2000545. doi: 10.1002/adfm.202000545.

Kuzmanov U, Wang EY, Vanderlaan R, Kim DH, Lee SH, Hadipour-Lakmehsari S, Guo H, Zhao Y, McFadden M, Sharma P, Billia F, Radisic M, Gramolini A, Emili A. Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nat Biomed Eng. 2020 Sep;4(9):889-900. doi: 10.1038/s41551-020-0585-y.

Xie R, Korolj A, Liu C, Song X, Lu RXZ, Zhang B, Ramachandran A, Liang Q, Radisic M. h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier. ACS Cent Sci. 2020 Jun 24;6(6):903-912. doi: 10.1021/acscentsci.9b01097.

Kinnear C, Agrawal R, Loo C, Pahnke A, Rodrigues DC, Thompson T, Akinrinade O, Ahadian S, Keeley F, Radisic M, Mital S, Ellis J. Everolimus Rescues the Phenotype of Elastin Insufficiency in Patient Induced Pluripotent Stem Cell-Derived Vascular Smooth Muscle Cells. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1325-1339. doi: 10.1161/ATVBAHA.119.313936.

Thavandiran N, Hale C, Blit P, Sandberg ML, McElvain ME, Gagliardi M, Sun B, Witty A, Graham G, Do VTH, Bakooshli MA, Le H, Ostblom J, McEwen S, Chau E, Prowse A, Fernandes I, Norman A, Gilbert PM, Keller G, Tagari P, Xu H, Radisic M, Zandstra PW. Functional arrays of human pluripotent stem cell-derived cardiac microtissues. Sci Rep. 2020 Apr 24;10(1):6919. doi: 10.1038/s41598-020-62955-3.

Liu C, Campbell SB, Li J, Bannerman D, Pascual-Gil S, Kieda J, Wu Q, Herman PR, Radisic M. High Throughput Omnidirectional Printing of Tubular Microstructures from Elastomeric Polymers. Adv Healthc Mater. 2022 Dec;11(23):e2201346. doi: 10.1002/adhm.202201346.

Wagner KT, Radisic M. A New Role for Extracellular Vesicles in Cardiac Tissue Engineering and Regenerative Medicine. Adv Nanobiomed Res. 2021 Nov;1(11):2100047. doi: 10.1002/anbr.202100047.

Ripken RM, Wood JA, Schlautmann S, Guenther A, Gardeniers HJGE, Le Gac S. Towards controlled bubble nucleation in microreactors for enhanced mass transport. React. Chem Eng. 2021,6, 1869-1877. doi: 10.1039/D1RE00092F.

Gao W, Vaezzadeh N, Chow K, Chen H, Lavender P, Jeronimo MD, McAllister A, Laselva O, Jiang JX, Gage BK, Ogawa S, Ramchandran A, Bear CE, Keller GM, Günther A. One-Step Formation of Protein-Based Tubular Structures for Functional Devices and Tissues. Adv Healthc Mater. 2021 Apr;10(8):e2001746. doi: 10.1002/adhm.202001746.

Malladi S, Miranda-Nieves D, Leng L, Grainger SJ, Tarabanis C, Nesmith AP, Kosaraju R, Haller CA, Parker KK, Chaikof EL, Günther A. Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction. ACS Biomater Sci Eng. 2020 Jul 13;6(7):4236-4246. doi: 10.1021/acsbiomaterials

Bannerman AD, Davenport Huyer L, Montgomery M, Zhao N, Velikonja C, Bender TP, Radisic M. Elastic Biomaterial Scaffold with Spatially Varying Adhesive Design. Adv Biosyst. 2020 Aug;4(8):e2000046. doi: 10.1002/adbi.202000046.

Savoji H, Davenport Huyer L, Mohammadi MH, Lun Lai BF, Rafatian N, Bannerman D, Shoaib M, Bobicki ER, Ramachandran A, Radisic M. 3D Printing of Vascular Tubes Using Bioelastomer Prepolymers by Freeform Reversible Embedding. ACS Biomater Sci Eng. 2020 Mar 9;6(3):1333-1343. doi: 10.1021/acsbiomaterials.9b00676.

Cheng RY, Eylert G, Gariepy JM, He S, Ahmad H, Gao Y, Priore S, Hakimi N, Jeschke MG, Günther A. Handheld instrument for wound-conformal delivery of skin precursor sheets improves healing in full-thickness burns. Biofabrication. 2020 Feb 3;12(2):025002. doi: 10.1088/1758-5090/ab6413

Norouzi M, Truong T, Jaenes K, Warner BM, Vendramelli R, Tierney K, Kobasa D, Tailor N, Plant P, Dos Santos C, Babiuk S, Ambagala A, Pardee K. Cell-Free Dot Blot: an Ultra-Low-Cost and Practical Immunoassay Platform for Detection of Anti-SARS-CoV-2 Antibodies in Human and Animal Sera. Microbiol Spectr. 2023 Jan 31;11(2):e0245722. doi: 10.1128/spectrum.02457-22.

Zargartalebi H, Yousefi H, Flynn CD, Gomis S, Das J, Young TL, Chien E, Mubareka S, McGeer A, Wang H, Sargent EH, Nezhad AS, Kelley SO. Capillary-Assisted Molecular Pendulum Bioanalysis. J Am Chem Soc. 2022 Oct 12;144(40):18338-18349. doi: 10.1021/jacs.2c06192.

Moon BU, Clime L, Hernandez-Castro JA, Brassard D, Nassif C, Malic L, Veres T. On-the-Fly Phase Transition and Density Changes of Aqueous Two-Phase Systems on a Centrifugal Microfluidic Platform. Langmuir. 2022 Jan 11;38(1):79-85. doi: 10.1021/acs.langmuir.1c01923.

Li BB, Scott EY, Olafsen NE, Matthews J, Wheeler AR. Analysis of the effects of aryl hydrocarbon receptor expression on cancer cell invasion via three-dimensional microfluidic invasion assays. Lab Chip. 2022 Jan 18;22(2):313-325. doi: 10.1039/d1lc00854d.

Moon BU, Clime L, Brassard D, Boutin A, Daoud J, Morton K, Veres T. An automated centrifugal microfluidic assay for whole blood fractionation and isolation of multiple cell populations using an aqueous two-phase system. Lab Chip. 2021 Oct 26;21(21):4060-4070. doi: 10.1039/d1lc00680k.

Zhang S, Elsayed M, Peng R, Chen Y, Zhang Y, Peng J, Li W, Chamberlain MD, Nikitina A, Yu S, Liu X, Neale SL, Wheeler AR. Reconfigurable multi-component micromachines driven by optoelectronic tweezers. Nat Commun. 2021 Sep 9;12(1):5349. doi: 10.1038/s41467-021-25582-8.

Zhang S, Li W, Elsayed M, Peng J, Chen Y, Zhang Y, Zhang Y, Shayegannia M, Dou W, Wang T, Sun Y, Kherani NP, Neale SL, Wheeler AR. Integrated Assembly and Photopreservation of Topographical Micropatterns. Small. 2021 Sep;17(37):e2103702. doi: 10.1002/smll.202103702.

Poncelet L, Malic L, Clime L, Geissler M, Morton KJ, Nassif C, Da Fonte D, Veilleux G, Veres T. Multifunctional magnetic nanoparticle cloud assemblies for in situ capture of bacteria and isolation of microbial DNA. Analyst. 2021 Oct 13. doi: 10.1039/d1an01297e.

Sklavounos AA, Lamanna J, Modi D, Gupta S, Mariakakis A, Callum J, Wheeler AR. Digital Microfluidic Hemagglutination Assays for Blood Typing, Donor Compatibility Testing, and Hematocrit Analysis. Clin Chem. 2021 Sep 28:hvab180. doi: 10.1093/clinchem/hvab180.

Sklavounos AA, Nemr CR, Kelley SO, Wheeler AR. Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform. Lab Chip. 2021 Sep 22. doi: 10.1039/d1lc00609f.

Zhang Y, Malekjahani A, Udugama BN, Kadhiresan P, Chen H, Osborne M, Franz M, Kucera M, Plenderleith S, Yip L, Bader GD, Tran V, Gubbay JB, McGeer A, Mubareka S, Chan WCW. Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device. Nano Lett. 2021 Jun 23;21(12):5209-5216. doi: 10.1021/acs.nanolett.1c01280.

Das J, Gomis S, Chen JB, Yousefi H, Ahmed S, Mahmud A, Zhou W, Sargent EH, Kelley SO. Reagentless biomolecular analysis using a molecular pendulum. Nat Chem. 2021 May;13(5):428-434. doi: 10.1038/s41557-021-00644-y.

Yousefi H, Mahmud A, Chang D, Das J, Gomis S, Chen JB, Wang H, Been T, Yip L, Coomes E, Li Z, Mubareka S, McGeer A, Christie N, Gray-Owen S, Cochrane A, Rini JM, Sargent EH, Kelley SO. Detection of SARS-CoV-2 Viral Particles Using Direct, Reagent-Free Electrochemical Sensing. J Am Chem Soc. 2021 Feb 3;143(4):1722-1727. doi: 10.1021/jacs.0c10810.

Moon BU, Malic L, Morton K, Jeyhani M, Elmanzalawy A, Tsai SSH, Veres T. Evaporation-Driven Water-in-Water Droplet Formation. Langmuir. 2020 Dec 1;36(47):14333-14341. doi: 10.1021/acs.langmuir.0c02683.

Lamanna J, Scott EY, Edwards HS, Chamberlain MD, Dryden MDM, Peng J, Mair B, Lee A, Chan C, Sklavounos AA, Heffernan A, Abbas F, Lam C, Olson ME, Moffat J, Wheeler AR. Digital microfluidic isolation of single cells for -Omics. Nat Commun. 2020 Nov 11;11(1):5632. doi: 10.1038/s41467-020-19394-5

Geissler M , Brassard D , Clime L , Pilar AVC , Malic L , Daoud J , Barrère V , Luebbert C , Blais BW , Corneau N , Veres T. Centrifugal microfluidic lab-on-a-chip system with automated sample lysis, DNA amplification and microarray hybridization for identification of enterohemorrhagic Escherichia coli culture isolates. Analyst. 2020 Oct 26;145(21):6831-6845. doi: 10.1039/d0an01232g.

Clime L, Malic L, Daoud J, Lukic L, Geissler M, Veres T. Buoyancy-driven step emulsification on pneumatic centrifugal microfluidic platforms. Lab Chip. 2020 Aug 26;20(17):3091-3095. doi: 10.1039/d0lc00333f.

Li BB, Scott EY, Chamberlain MD, Duong BTV, Zhang S, Done SJ, Wheeler AR. Cell invasion in digital microfluidic microgel systems. Sci Adv. 2020 Jul 15;6(29):eaba9589. doi: 10.1126/sciadv.aba9589.

Geissler M, Malic L, Morton KJ, Clime L, Daoud J, Hernández-Castro JA, Corneau N, Blais BW, Veres T. Polymer Micropillar Arrays for Colorimetric DNA Detection. Anal Chem. 2020 Jun 2;92(11):7738-7745. doi: 10.1021/acs.analchem.0c00830

Dixon C, Lamanna J, Wheeler AR. Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device. Lab Chip. 2020 May 19;20(10):1845-1855. doi: 10.1039/d0lc00302f.

Zhong J, Riordon J, Wu TC, Edwards H, Wheeler AR, Pardee K, Aspuru-Guzik A, Sinton D. When robotics met fluidics. Lab Chip. 2020 Feb 21;20(4):709-716. doi: 10.1039/c9lc01042d.